University of Catania

education 📍 Catania, Italy
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University of Catania
1
EM Publications
4
EM Researchers

Associated Institutions

Istituto Nazionale di Fisica Nucleare, Sezione di Catania
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Centro Siciliano di Fisica Nucleare e di Struttura della Materia
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Erythromelalgia Researchers

Cacciola RR
1 EM publication • h-index: 23
Cipolla A
1 EM publication • h-index: 10
Di Francesco E
1 EM publication • h-index: 6
Cacciola E
1 EM publication • h-index: 20

Publications

Treatment of symptomatic patients with essential thrombocythemia: effectiveness of anagrelide.

Cacciola RR, Cipolla A, Di Francesco E, Giustolisi R, Cacciola E
American journal of hematology •

We prospectively evaluated the effect of anagrelide (ANA) on platelets, PF4, F1+2, PAP, PAI-1, and TFPI and erythromelalgia in patients with essential thrombocythemia (ET) receiving anti-aggregants both pre- and post-ANA. At first, we observed a successful reduction of platelets, which was associated with normalization of platelet coagulant and endothelial function and disappearance of erythromelalgia. Secondly, we found a correlation between PF4 and TFPI and between TFPI and thrombosis, suggesting that erythromelalgia may be caused by platelet-mediated endothelial activation. These data may indicate that ANA may be efficacy in the treatment of symptomatic patients with ET.

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